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The International Society for Medical Education Pvt. Ltd. (ISME Pvt. Ltd.) - non profit organisation had an agreement with Government of Nepal, which was signed on 8th August 1993 to establish the College of Medical Sciences - at Bharatpur for medical education, promotion of health and training Para-Medical staff in Nepal.
In reality the institution was established under the pioneer leadership of Mr. Nagender K. Pampati, a young MBA from Boston, USA, the Managing Director and Architect of this newly established Institution. The institution has been continuously progressing under the dynamic leadership of young medical graduate from the same institution and the Director of ISME Pvt. Ltd. Dr. V. Natraj Prasad.
College of Medical Sciences is currently headed by Professor A.C. Patowary, FRCPE, DPH (Edin.) as the principal, who was formerly Professor and Head of the Department of Community Medicine, Guwahati Medical College, Director of Medical Education, Planning and Research and Director of Health Services, Government of Assam, India.